Renal ischemia-reperfusion increases endothelial VEGFR-2 without increasing VEGF or VEGFR-1 expression
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چکیده
منابع مشابه
Constitutive expression of VEGF, VEGFR-1, and VEGFR-2 in normal eyes.
PURPOSE The expression of vascular endothelial growth factor (VEGF) and its high-affinity receptors VEGFR-1 and VEGFR-2 was investigated in normal eyes. METHODS Monkey and rat eyes were surgically removed in animals under deep anesthesia and immediately prepared for study. Ocular VEGF, VEGFR-1, and VEGFR-2 expression was studied using a combination of in situ hybridization, northern blot anal...
متن کاملModulation of VEGFR-2-mediated endothelial-cell activity by VEGF-C/VEGFR-3.
Vascular endothelial growth factor (VEGF) receptor 3 (VEGFR-3), a receptor for VEGF-C, was shown to be essential for angiogenesis as well as for lymphangiogenesis. Targeted disruption of the VEGFR-3 gene in mice and our previous study using an antagonistic monoclonal antibody (MoAb) for VEGFR-3 suggested that VEGF-C/VEGFR-3 signals might be involved in the maintenance of vascular integrity. In ...
متن کاملSelective imaging of VEGFR-1 and VEGFR-2 receptors using 89Zr-labeled single-chain VEGF mutants
Vascular endothelial growth factor A (VEGF) acts via two vascular endothelial growth factor receptors VEGFR-1 and VEGFR-2 that play important and distinct roles in tumor biology. We reasoned that selective imaging of these receptors could provide unique information for diagnostics and for monitoring and optimizing responses to anti-cancer therapy, including antiangiogenic therapy. Herein, we re...
متن کاملClinicopathological correlation and prognostic significance of VEGF-A, VEGF-C, VEGFR-2 and VEGFR-3 expression in colorectal cancer.
BACKGROUND Colorectal cancer (CRC) is the third most common type of cancer and the fourth most frequent cause of cancer death. Literature indicates that vascular endothelial growth factor is a predominant angiogenic factor and that angiogenesis plays an important role in the progression of CRC. PATIENTS AND METHODS The present series consisted of tissue samples obtained from 672 patients who ...
متن کاملGlioma cells enhance endothelial progenitor cell angiogenesis via VEGFR-2, not VEGFR-1.
Although potential contribution of endothelial progenitor cells (EPCs) to angiogenesis in glioma has been proposed, the molecular mechanisms of EPCs recruitment to vasculature have not been fully elucidated. Here, we show that the supernatant from glioma cells promotes EPCs angiogenesis via VEGFR-2, not VEGFR-1. Moreover, VEGFR-2 siRNA inhibits VEGFR-2 expression in EPCs, tube formation on matr...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2002
ISSN: 0085-2538
DOI: 10.1046/j.1523-1755.2002.00329.x